Skin rash on face and chest I just started Prozac 20mg 3 days noticed rash or hives last night but? Asked 6 Mar 2014 by Shars Updated 9 March 2018 Prozac is a type of antidepressant called a selective serotonin reuptake inhibitor used for treating depression, bulimia, obsessive-compulsive disorder , panic disorder, and premenstrual dysphoric disorder. Prozac is available in generic form. my 11 year old son had a virus on Thanksgiving 5 days later he started itching from head to toe no rash no hives nothing. we started him on benadryl and calamine lotiong, not relief so the Doctor gave him allegra and cortisone, no relief. Can Prozac cause Hives? Hives is a known side effect of Prozac. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Hives is a known side effect of Prozac. Prozac should be stopped immediately if you get hives as soon as you start taking it (in the first couple of weeks). It can be a sign of a rare but serious allergic reaction called Steven's Johnson Syndrome. In this report we describe a patient who developed pruritus and skin rash from chocolate, but only when he was under SSRI-treatment. The case is presented and we provide a putative biological rationale for the described phenomenon. my 11 year old son had a virus on Thanksgiving 5 days later he started itching from head to toe no rash no hives nothing. we started him on benadryl and calamine lotiong, not relief so the Doctor gave him allegra and cortisone, no relief. I've been on fluoxitine for 6 weeks and I have developed a severe rash and hives. They deminish with sleep but come back through out the day. really bad at night when i'm around my kids who are quite needy. Along with its needed effects, fluoxetine (the active ingredient contained in Prozac) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.